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While Alnylams Phase III APOLLO-B study hit both key primary and secondary endpoints, the FDA stated in the documents that the effects of patisiran compared to placebo on both endpoints were small, of questionable clinical meaningfulness, and may not be detectable by patients. Major discussion points during the adcomm meeting included whether these key endpoints were appropriate to ascertain clinical meaningfulness in the ATTR-CM population, and panelists expressed varying opinions on whether the magnitude of the benefit seen in trial data was clinically meaningful

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Potential Alternative for ED (Men): For men who do not respond to or cannot take PDE-5 inhibitors, PT-141 may offer a centrally acting alternative that could help initiate and maintain erections

J Gastrointest Surg Off J Soc Surg Aliment Tract 13(2):312317

Intestinal serotonin transporter inhibition by toll-like receptor 2 activation